Method Development and Validation

Our food method development and validation services can support you with obtaining a specific, robust and fit for purpose analytical method.

Method Development and Method Validation in Food Products

There are many reasons why you may need to develop and validate methods for quantifying your functional ingredients: using new raw materials or formulations, the need to comply with new and relevant legislation, and changes to the manufacturing process or analytical procedures are just some examples.

It is important to ensure that the chosen analytical methods are suitable for the intended purpose. You need to ensure that the extraction procedures you use are appropriate for both the compound of interest and the food matrix type, taking into account the levels of the compound/s, solubility, encapsulation, different chemical structures and the complexity of the food matrix itself. Then, the analytical technique used to quantify the analyte of interest must be effective, accurate and reliable. Our multi-disciplinary teams have the specialist knowledge and expertise needed to develop fit-for-purpose methods tailored to your needs.

You can also trust us to perform robust validation of both new and optimised methods which means you can have confidence in your methods as part of your food product development.  

Techniques include:-

  • UltraViolet-Visible (UV/VIS)
  • High-Performance Liquid Chromatography with UV or Diode Array Detection (HPLC-DAD)
  • High-Performance Liquid Chromatography with Fluorescence Detection (HPLC-FLD)
  • High-Performance Liquid Chromatography with Refractive Index Detection (HPLC-RID)
  • Gas Chromatography with Flame Ionisation Detection (GC-FID)
  • Gas Chromatography - Mass Spectrometry (GC-MS)
  • Ion Chromatography with Conductivity Detection (IC-CD)
  • High-Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD)
  • Liquid Chromatography - Mass Spectrometry (LC-MS)
  • Atomic Absorption Spectroscopy (AAS)
  • Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

Method parameters including:-

  • Specificity
  • Limits of detection and quantification
  • Linearity
  • Accuracy
  • Precision
  • Solution stability

More Resources

Specialist Scientific Services - RSSL Brochure
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Analytical Issues in Functional Foods - White Paper
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Method Development and Validation for Nutraceuticals - White Paper
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For any questions regarding our services, getting a proposal or submitting samples, please contact the team on:

t: +44 (0)118 918 4076