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Satiety difference between fructose and glucose

9 Jan 2013

Many media outlets carried news relating to a preliminary communication published in Journal of American Medical Association, in which researchers had studied neurophysiological factors that might underlie associations between fructose consumption and weight gain.   The researchers recruited twenty healthy adult volunteers who underwent 2 magnetic resonance imaging sessions at Yale University in conjunction with fructose or glucose drink ingestion in a blinded, random-order, crossover design. The researchers measured the relative changes in hypothalamic regional cerebral blood flow (CBF). Secondary outcomes included whole brain analyses to explore regional CBF changes, functional connectivity analysis to investigate correlations between the hypothalamus and other brain region responses, and hormone responses.  It was found that glucose ingestion reduced the activation of the hypothalamus, insula, and striatum—brain regions that regulate appetite, motivation, and reward processing. Glucose ingestion also increased functional connections between the hypothalamic striatal network and increased satiety. By contrast, fructose consumption was associated with reduced systemic levels of the satiety-signalling hormone insulin and glucagon-like polypeptide 1 levels.   These neuroimaging findings are consistent with animal studies reporting that the central administration of fructose provokes feeding in rodents, whereas centrally administered glucose suppresses food intake. Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance. This research offers a potential explanation for the correlation between fructose consumption and weight gain. 

RSSL's Functional Ingredients Laboratory can determine fructose by HPLC.  For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

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