12 January - 20 June 2016

Anti cancer properties of soya

10 April 13

A group from the University of Arkansas report results in Food Research International that indicate that peptide fractions derived from soybean meal can act against colon, liver and lung cancer cell proliferation. While processed animal meats are linked with health concerns including cancer and heart disease due to the presence of nitrosamines, soy protein is widely considered to promote health without causing any detrimental health conditions. In this study, the researchers took protein from soybeanmeal, (the residue after oil extraction from seeds) and tested for bioactivity against colon, liver and lung cancer cell lines in vitro.  Three soybean lines were used and protein hydrolysates of different sizes were tested against human colon (HCT-116, Caco-2), liver (HepG-2) and lung (NCL-H1299) cancer cell lines. A cytotoxicity assay was performed to test in vitro cancer cell viability following treatment with the peptide fractions.  The peptide fractions from two of the soybeans (N98-4445A and S03-543CR) showed cell growth inhibition of 73% of colon cancer (HCT-116), 70% of liver cancer cells and 68% of lung cancer cells. Dose response studies showed that the peptides had significant inhibitory effect at higher concentrations (1000 μg/mL to 600 μg/mL) and gradually decreased with decreased dosage (500 μg/mL to 100 μg/mL). Reverse phase HPLC identified three single peptides from the 10–50 kDa fractions of N98-4445A soy line that have potential for enhanced activity. The researchers therefore conclude that soybean peptide fractions can be a source of bioactivity against colon, liver and lung cancer cell proliferation.

RSSL's Functional Ingredients Laboratory can determine daidzein, genistein and other soya isoflavones by HPLC. For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

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