12 January - 20 June 2016

Impact of coffee consumption on breast cancer

8 May 13

A study by researchers from Lund University, Sweden, published in Cancer Causes & Control has investigated the impact of coffee consumption on tumour characterisation and risk for early events in relation to breast cancer and CYP1A2 and CYP2C8 genotypes which contribute to tamoxifen and caffeine metabolism.  Jernstrom et al. collected data from 634 Swedish breast cancer patients with a mean age of 59.6 years.  Of these participants approximately 300 took Tamoxifen, a common hormone therapy used after breast cancer surgery which reduces the risk of new tumors by blocking oestrogen receptors.   The women were asked to complete questionnaires preoperatively, on clinical follow up visits, and postoperatively.  During preoperative visits, body weight, height, waist and hip circumferences and breast volumes were measured and lifestyle factors recorded.  Clinical data and tumour characteristics were obtained.  Coffee intake was reported using questionnaires which provided nine consumption levels ranging from 0 to 8+ cups of coffee a day. Blood samples were used to measure genotyping, and tumour size recorded. Jernstrom et al report the main finding of the study was that tamoxifen treatment combined with moderate to high coffee consumption was associated with less than half the risk of an early breast cancer event (including local or regional recurrence, new breast cancer, or distant metastases) compared with low consumption.  Low coffee consumption combined with any CYPIA2*1F C-allele or CYPc8*3 was associated with an over threefold risk for an early breast cancer event in tamoxifen-treated patients.   As the study found a strong association between moderate to high coffee consumption and hormone receptor status, the researchers predicted that coffee may influence the expression of oestrogen receptors and progesterone receptors and modulate the relationship between the two.  

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