12 January - 20 June 2016

Tomato and soy in cancer prevention

22 May 13

A paper published in Cancer Prevention Research reports a study to determine the efficacy of dietary tomato and soy germ, alone and in combination, for the inhibition of prostate carcinogenesis (PCa) in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Male mice, predisposed to prostate cancer were randomised to consume AIN-93G control, 10% whole tomato powder (TP), 2% soy germ powder (SG) or 10% tomato powder with 2% soy germ powder (TP+SG) for 14 weeks.  100% of mice fed the control diet had PCa, while PCa incidence was significantly lower in mice consuming TP (61%, p<0.001), SG (66%, p<0.001) and TP+SG (45%, p<0.001). Although the protection offered by the combination of TP and SG was not synergistic, it was the most effective intervention. Over half of the TRAMP mice that consumed the combination of TP+SG were without a single cancerous lesion in the prostate compared to 100% cancer incidence in the control group. This suggests a positive interaction between tomato and soy foods for prevention (not treatment) of prostate cancer.  The authors conclude that their study reinforces the recommendations of many organisations that a variety of fruits and vegetables should serve as the foundation of a healthy diet. It also suggests that continued efforts to develop novel functional foods containing an array of bioactives are a reasonable strategy for prostate cancer prevention or as an adjunct to therapy. Novel tomato-soy food products with defined and consistent composition might be usefully developed for future clinical trials.

RSSL's Functional Ingredients Laboratory can quantify lycopene in tomato-based products. For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

RSSL's Functional Ingredients Laboratory can determine daidzein, genistein and other soya isoflavones by HPLC. For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

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