12 January - 20 June 2016

Mice study investigates link between pancreatic cancer and a high fat, high calorie diet

9 Oct 13

A mouse study published in Cancer Prevention Research by researchers from UCLA’s Jonsson Comprehensive Cancer Centers has reported a link between obesity and pancreatic cancer.  Previous studies have reported a positive association between obesity and increased risk of pancreatic cancer although Eibl et al note that no studies had previously modelled human pancreatic cancer in animals.  The team used a genetically engineered mouse model that had the same genetic mutation found in human pancreatic cancer patients.  Eibl et al. split the mice into two sets and fed one group a  high fat, high calorie diet containing approximately 4,535 kcal/kg; 40% of calories from fats, and the other set a low fat diet containing approximately 3,725 kcal/kg; 12% of calories from fats for 4 months. The team found that the mice eating the normal diet gained around 7.2 g, whereas the mice fed the high fat and high calories gained around 15.9 g. The mice consuming the diet high in fat and calories had abnormalities of their metabolism, increased insulin levels and had marked pancreatic tissue inflammation and development of PanIN lesions. The mice fed the normal diet however had mostly normal pancreases with very few scattered PanIN lesions.  The scientists report that these findings indicate that these markers are precursors to cancers, noting that the development of these lesions in mice is very similar to what happen in humans.  They state: “These lesions take a long time to develop into cancer, so there is enough time for cancer-preventive strategies such as changing to a lower-fat, lower-calorie diet, to have a positive effect.” 

RSSL's Product and Ingredient Innovation Team has considerable expertise in developing a wide range of food and drink products at a laboratory and pilot scale.  For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

share this article
RSSL endeavours to check the veracity of news stories cited in this free e-mail bulletin by referring to the primary source, but cannot be held responsible for inaccuracies in the articles so published. RSSL provides links to other World Wide Web sites as a convenience to users, but cannot be held responsible for the content or availability of these sites. This document may be copied and distributed provided the source is cited as RSSL's Food e-News and the information so distributed is not used for profit.

Previous editions

Load more editions

Make an Enquiry