12 January - 20 June 2016

Changing the paradigm for obesity interventions

9 Oct 13

The outcome of a study published in the Journal of Lipid Research on muscle activity and exercise endurance in mice prompts a research team from University of Wisconsin-Madison to argue for a paradigm shift in treatments for obesity.  They examined activity of an enzyme Stearoyl-CoA desaturase (SCD)1, which converts saturated fatty acids into monounsaturated fatty acids. Using muscle overexpression, they sought to determine the role of SCD1 expression in glucose and lipid metabolism and its effects on exercise capacity in mice.  They found that SCD1 overexpression was associated with increased triglyceride (TG) content. The fatty acid composition of the muscle revealed a significant increase in polyunsaturated fatty acid (PUFA) content of TG, including linoleate (18:2n6). Untrained SCD1-Tg mice also displayed significantly increased treadmill exercise capacity, and other benefits such as decreased fasting glucose.  The team argues that their data suggest that overexpression of SCD1, at least in muscle, provides a far greater benefit on metabolic function than does suppressing its activity. Current pharmacological interventions for obesity focus on suppression of SCD1, but its success is associated with an increased risk for atherogenesis.  The Wisconsin team argues that nutritional and/or lifestyle interventions aimed at increasing muscle SCD1 activity and PUFA content should be strongly considered as alternative therapy. They note 'If enhanced SCD1 activity in skeletal muscle is sufficient to decrease fasting glucose, while increasing fat oxidation and exercise capacity, then means to suppress its activity should be avoided or at least used with caution. Instead, it may prove to be more efficacious to use dietary supplementation of PUFA either alone or in combination with aerobic exercise training to increase overall metabolic health.'

RSSL's Lipids Laboratory, part of the Investigative Analysis Team can determine the fatty acid profile of all dietary fats and oils. For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

share this article
RSSL endeavours to check the veracity of news stories cited in this free e-mail bulletin by referring to the primary source, but cannot be held responsible for inaccuracies in the articles so published. RSSL provides links to other World Wide Web sites as a convenience to users, but cannot be held responsible for the content or availability of these sites. This document may be copied and distributed provided the source is cited as RSSL's Food e-News and the information so distributed is not used for profit.

Previous editions

Load more editions

Make an Enquiry