12 January - 20 June 2016

Polyphenols and oxidative stress

9 Oct 13

A mixed picture arises from a study of the effects of polyphenol supplementation during intensive exercise.  The research team at the North Carolina Research Campus (NCRC) in Kannapolis report discovery of enhanced polyphenolic absorption via the colon into the blood stream, and increased ketogenesis 14 hours after exercise in athletes that consumed polyphenol supplements. However, the primary investigation into the ability of polyphenols to act as a countermeasure to inflammation and oxidative stress showed no significant benefits. The study published in PLOS One used supplementation with water soluble polyphenols from blueberry and green tea extracts captured onto a polyphenol soy protein complex (PSPC). The administered dose was equivalent to consuming three cups of blueberries and just over a cup of brewed green tea.  Blood samples were collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running in subjects completing all aspects of the study (N = 16 PSPC, N = 15 placebo), and analyzed using a metabolomics platform with GC-MS and LC-MS. Metabolites characteristic of gut bacteria metabolism of polyphenols were increased with PSPC and 3 d running, an effect which persisted for 14-h post-exercise. Fatty acid oxidation and ketogenesis were induced by exercise in both groups, with more ketones at 14-h post-exercise in PSPC. However, established biomarkers for inflammation (CRP, cytokines) and oxidative stress (protein carbonyls) did not differ between groups, possibly questioning whether anti-inflammatory effects observed in in vitro studies have much relevance to what actually happens in the body.

RSSL's Functional Ingredients Laboratory can assay a range of products for polyphenolic components. For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

RSSL's Functional Ingredients Laboratory can analyse green tea for catechins, including epigallocatechin-gallate (EGCG) and epigallocatechin (EGC). For more information please contact Customer Services on Freephone 0800 243482 or email enquiries@rssl.com

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