Host cell DNA & protein services

RSSL can conduct a wide range of analyses to support the identification of in-process host cell DNA and host cell protein contamination in biopharmaceuticals.


As biopharmaceuticals are produced within living cells, impurities - such as host cell DNA and host cell proteins (HCPs) - may arise during the manufacturing process that are derived from the production system. 


Both host cell DNA and proteins pose a risk to patient safety, due to potential oncogenicity, infectivity and immunomodulatory effects. As a result, regulatory agencies have stringent guidelines for safe levels which need to be met before approval.  


Our scientists are experts in the accurate and sensitive quantitation of host cell DNA impurities, whether encountered at the drug discovery stage or in production. They are also able to perform both generic HCP assays and validated product-specific HCP assays after proper assay transfer to RSSL. 

Our techniques


We offer a range of techniques for the quantitation of host cell DNA and proteins, including:  


  • Western-Blotting 
  • 2-D PAGE 
  • Real-Time Polymerase Chain Reaction (RT-PCR) 
  • High throughput host cell DNA analyses with the MagMAX™ Sample Preparation System 
  • Spectrophotometric DNA quantification with PicoGreen® dsDNA quantitation assay 

BMA R2 5950 HR BMA R2 6029 HR Istock 1094847354

Contact us

Need to get in touch? Either complete the enquiry form or call us:

Switchboard: +44 (0)118 918 4000

Customer Services: +44 (0)118 918 4076

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