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Unknown impurities can arise at all stages of the pharmaceutical R&D lifecycle, from drug discovery through to commercialisation. Identifying and eliminating these impurities is essential to help protect patient safety. RSSL’s expertise in isolating and identifying impurities enables us to play a key role in helping you to research, develop and manufacture high quality pharmaceutical products.
Preparative scale isolation is first carried out using chromatographic techniques and post-purification treatment, such as freeze drying. Advanced spectroscopic techniques can then be employed to identify the impurities of interest. Once the impurity has been identified, we also offer further scale-up for the isolation of larger quantities of impurities for use as reference materials.
We also provide support with the development of sample purification methods. This includes support with scaling up your existing methods or developing bespoke reproducible purification approaches for your products and APIs.
At RSSL, we offer a range of analytical techniques for impurity isolation and sample purification, including:
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