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GC-MS is a powerful analytical technique that combines gas chromatography (GC) with mass spectrometry (MS). In this technique, a sample is first separated using GC, and the individual components are then ionized and fragmented in the mass spectrometer, generating a mass spectrum that can be used to identify the individual components of the sample. GC is known for its high sensitivity and selectivity, making it suitable for the analysis of trace levels of compounds in complex matrices. This technique is widely used in the analysis of volatile and semi-volatile compounds, such as those found in environmental samples, cosmetics, food and beverages, and pharmaceuticals.
Liquid Chromatography Mass Spectrometry (LC-MS/MS) combines liquid chromatography (LC) with tandem mass spectrometry (MS/MS). In this technique, a sample is first separated using LC, and the individual components are then ionized and fragmented in the mass spectrometer, generating a mass spectrum that can be used to identify and quantify the individual components of the sample. LC-MS/MS is widely used in the analysis of non-volatile and polar compounds, such as those found in biological samples, food and beverages, and pharmaceuticals.
PTR-TOF-MS uses proton transfer reactions to ionise and detect volatile organic compounds (VOCs) in the gas phase. In this technique, a sample is introduced into a reaction chamber where it reacts with a protonated reagent gas, generating a mass spectrum that can be used to identify and quantify the individual VOCs in the sample, after ionisation, the ions are accelerated into a TOF mass spectrometer, where they are separated based on their mass-to-charge ratios. The time taken for ions to reach the detector is used to determine their mass. The combination of PTR and TOD enables real-time detection of compounds with minimal sample preparation.
· PTR-TOF-MS (IONICON analytik)
Used to determine the concentration of elements in a wide range of samples. ICP-MS is a highly sensitive analytical technique used for the detection of elements at parts per billion (ppb) and parts per trillion (ppt) levels. It's particularly powerful for trace element analysis due to its high sensitivity, wide dynamic range, and multi-element capability. ICP-MS works by ionising the atoms of the elements in a sample using a high-temperature inductively coupled plasma, and then separating and detecting those ions based on their mass-to-charge ratio using a mass spectrometer. A benefit of the ICP-MS technique is the ability to analyse multiple elements simultaneously to produce reliable, reproducible results.