Harnessing automation to scale up traditional cloud point testing

 

RSSL's innovative solution transforms approach to scale up analysis.

 

We took the traditional, time-consuming manual cloud point test and adapted it for automation, giving the client an innovative new method to increase the volume of samples they could analyse in the required time frame.

 

The challenge

 

A client approached RSSL with a need to automate the cloud point test for the analysis of a large number of eco-friendly detergent samples. The traditional manual method can be time-consuming and therefore not scalable for the volume of samples required.

 

With a strong reputation in analytical development, RSSL was tasked with delivering a solution that would meet both the quality standards and client’s tight deadlines.

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Our expert problem solving

 

Our highly skilled analysts adapted the manual, compendial cloud point tests for Octoxinol 10 EP and Nonoxynol 9 USP for use with the advanced MP80 melting point apparatus. The validation approach involved conducting precision and intermediate precision studies using both the traditional manual methods and the adapted automated method. 

 

All results were rigorously compared to ensure consistency and accuracy across methodologies. The process was carried out in full compliance with USP <1225> guidelines for Category III methods, ensuring the repeatability and reproducibility required for robust validation.

Successful solution

 

Our method adaptation was rapidly checked for feasibility and subsequent validation and implementation of the automated cloud point method. This streamlined approach allowed for both analysis of large sample volumes efficiently within the required timeline whilst still maintaining compliance with stringent quality standards.


By automating the test, RSSL not only delivered a scalable solution but also demonstrated the capability to adapt and innovate under tight deadlines, solidifying its position as a trusted partner in analytical solutions.

Find out how we can provide solutions to complex challenges in method development and validation

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