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Sections 4.33 to 4.36 of the 2022 edition of EU GMP Annex 1 focus on cleaning and disinfection. In this GMP blog, we look at cleaning and disinfection techniques.
For effective cleaning, the application technique is important. Wiping strategy includes the applied pressure force, wiped surface area, the geometry of the mechanical action, the number of passages. Each of these is influenced by the presentation.
There are five primary means of application:
Spray, with no wiping
Spray and wipe
Dip and wipe
Soak and wipe
Pre-saturated wipes or mop heads
Based on the above, the cleaning technique used for cleanrooms should be defined and standardised. It does not matter how effective the cleaning agents selected are if the cleaning technique practiced by cleanroom operators is poor.
Training: Our cleaning validation course explores the issues and pitfalls you may experience and includes guidance on techniques to overcome the issues in order to achieve a successful outcome. To view all our training courses, please click here.
Annex 1 webinar series: Dr Tim Sandle has collaborated with RSSL on an insightful series covering key Annex 1 focus areas. To learn more and view the series please click here.
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