We used the LUMiSizer, an analytical centrifuge combined with NIR light extinction measurement, to evaluate the stability of numerous reformulated fillings against the originals. This enabled us to track the development and movement of any phase interfaces, such as changes caused by sedimentation (see figure 1).
From this data, we could then predict which of the new formulations would retain their intended structure for the longest.
Working with this centrifugal method also enabled us to run the entire test under the influence of multiple gravities and accelerate any physical instability processes – significantly reducing development time. We evaluated a 12-month shelf life in just four hours.
Figure 1. LUMiSizer tracking of sedimentation process, images adapted from https://lum-gmbh.com.